Donald C Lo Selected Research

PBI-05204

12/2016	Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.
1/2014	BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.
11/2011	In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.

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Donald C Lo Research Topics

Disease

15	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2017 - 09/2008
15	Huntington Disease (Huntington's Disease) 12/2017 - 09/2008
7	COVID-19 11/2021 - 01/2020
6	Ischemic Stroke 01/2018 - 07/2006
4	Neoplasms (Cancer) 12/2019 - 11/2011
3	Virus Diseases (Viral Diseases) 11/2021 - 01/2021
3	Glioblastoma (Glioblastoma Multiforme) 12/2019 - 10/2016
3	Hypoxia (Hypoxemia) 01/2018 - 07/2006
3	Stroke (Strokes) 12/2016 - 11/2011
3	Alzheimer Disease (Alzheimer's Disease) 12/2016 - 09/2010
3	Ischemia 01/2016 - 07/2006
2	Infections 01/2021 - 05/2020
2	Emerging Communicable Diseases (Emerging Infectious Diseases) 08/2020 - 01/2020
2	Infarction (Infarctions) 01/2016 - 01/2013
2	Disease Progression 08/2013 - 01/2011
1	Pain (Aches) 01/2022
1	Human Influenza (Influenza) 10/2021
1	Coronavirus Infections 10/2021
1	Zika Virus Infection 01/2021
1	Neuroinflammatory Diseases 01/2017
1	Frontotemporal Dementia (Semantic Dementia) 12/2016
1	Cerebral Infarction 01/2016
1	Central Nervous System Diseases (CNS Diseases) 05/2015
1	Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia) 03/2014
1	Brain Injuries (Brain Injury) 01/2013
1	Down Syndrome (Down's Syndrome) 11/2012
1	Amyloid Plaque 09/2010
1	Atrophy 09/2010
1	Nervous System Diseases (Neurological Disorders) 05/2010
1	Polyps 09/2008
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 07/2006
1	Heart Failure 07/2006

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 11/2021 - 09/2008
11	polyglutamineIBA 12/2017 - 09/2008
5	Huntingtin ProteinIBA 10/2016 - 05/2010
3	Drug CombinationsIBA 11/2021 - 05/2020
3	Amyloid (Amyloid Fibrils)IBA 12/2016 - 05/2015
3	PBI-05204IBA 12/2016 - 11/2011
3	Cardiac GlycosidesIBA 01/2014 - 07/2006
2	Chloroquine (Aralen)FDA LinkGeneric 11/2021 - 05/2020
2	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 11/2021 - 05/2020
2	EnzymesIBA 12/2020 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 03/2014
2	Neuroprotective AgentsIBA 01/2017 - 01/2016
2	Phosphotransferases (Kinase)IBA 11/2012 - 09/2010
1	Opioid Analgesics (Opioids)IBA 01/2022
1	Niclosamide FDA Link 01/2021
1	Viral ProteasesIBA 01/2021
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2021
1	Antiviral Agents (Antivirals)IBA 01/2021
1	NucleosidesIBA 12/2020
1	remdesivirIBA 12/2020
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 12/2020
1	VaccinesIBA 12/2020
1	Thymidine KinaseIBA 12/2019
1	CopperIBA 01/2018
1	NSC319726IBA 01/2018
1	MetalsIBA 01/2018
1	PurinesIBA 01/2018
1	XenobioticsIBA 01/2018
1	Interleukin-4 (Interleukin 4)IBA 01/2018
1	CytokinesIBA 01/2018
1	SphingolipidsIBA 01/2017
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	sphingosine 1-phosphate lyase (aldolase)IBA 01/2017
1	Caspase 3 (Caspase-3)IBA 01/2016
1	Interleukin-21 ReceptorsIBA 01/2016
1	ThiazolesIBA 01/2016
1	Protein Disulfide-IsomerasesIBA 04/2015
1	ClathrinIBA 04/2014
1	AMPA Receptors (AMPA Receptor)IBA 04/2014
1	Ataxin-1IBA 04/2014
1	Molecular Chaperones (Chaperone, Molecular)IBA 04/2014
1	Superoxide Dismutase-1IBA 04/2014
1	Messenger RNA (mRNA)IBA 01/2013
1	IntegrinsIBA 01/2013
1	Dyrk KinasesIBA 11/2012
1	Oxygen (Dioxygen)IBA 11/2011
1	oleandrinIBA 11/2011
1	Glucose (Dextrose)FDA LinkGeneric 11/2011
1	Caspase InhibitorsIBA 11/2010
1	Glutamine (L-Glutamine)FDA Link 11/2010
1	JNK Mitogen-Activated Protein KinasesIBA 09/2010
1	Amino Acids FDA Link 09/2008
1	Proline (L-Proline)FDA Link 09/2008
1	EpitopesIBA 09/2008
1	Adenosine Triphosphatases (ATPase)IBA 07/2006
1	neriifolinIBA 07/2006
1	Digitoxin FDA Link 07/2006
1	Digoxin (Digitek)FDA LinkGeneric 07/2006

Therapy/Procedure

14	Therapeutics 01/2022 - 11/2012
1	Deep Hypothermia Induced Circulatory Arrest 01/2017
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2017